| dc.description.abstract | he purpose of this review literature is to look at the
mechanism of mesenchymal stem cell secretome in the regeneration
of periodontal tissue.
Methods: This literature review was collected from several
journals and research that has been done, where the application of
Mesenchymal stem cells (MSCs) promises a favourable result for cellbased therapy in inflammatory diseases, immune system disorders,
regeneration, and tissue repair.
Results: MSCs possess a potent immunomodulatory function, paracrine
effects, and the ability to differentiate into different cells. Not only
mesenchymal stem cells can replace damaged tissue or cells but also
secrete secretome namely bioactive ingredients such as cytokines,
chemokines, growth factors, pro- inflammatory, and anti-inflammatory
which play an essential role in regulating the host immune system.
Periodontal disease is an inflammatory disease that occurs in the teeth
supporting structures. Lately, many therapies for periodontal disease
utilized MSCs from gingival tissue and periodontal ligaments. Secretome
activates endogenous MSCs to improve the immune system in periodontal
disease that might create a better microenvironment of periodontal tissue.
Conclusion: The secretome of MSCs has attracted a lot of attention
and has the potential to repair and regenerate tissues including
periodontal tissue. | en_US |
