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dc.contributor.authorSenjarini, K
dc.contributor.authorNuryady, M.M
dc.contributor.authorFebriyantiningsih, D.E
dc.contributor.authorSpecht, S
dc.date.accessioned2017-08-07T02:00:38Z
dc.date.available2017-08-07T02:00:38Z
dc.date.issued2017-08-07
dc.identifier.urihttp://repository.unej.ac.id/handle/123456789/80869
dc.descriptionFMIPA Universias jember Jl. Kalimantan 37 jemberen_US
dc.description.abstractExposure to arthropod vectors of infectious diseases such as malaria has been associated with specific antibody responses against salivary glands protein among people living in endemic area. To examine the effects of salivary gland extract proteins (SGEP) from Anopheles sundaicus on human immune response (in vitro), we have conducted the quantification of IgG levels using ELISA and PBMC culture. Here we demonstrated that antisalivary antibodies (IgG) levels against salivary gland extract protein (SGEP) from An. sundaicus were higher in healthy people from malaria endemic area (Bangsring, Banyuwangi) than those from a non-malarious area, and occurred predominantly in 11-40 years age groups which have been considered as a result of long and continuous exposure to malaria mosquito. Furthermore, the An. sundaicus SGEP was observed to polarize the host immune response towards a type 2 (Th2) responses, characterized by up-regulating Th2 cytokines (IL-10) and down-regulating Th1 cytokines (IFN )en_US
dc.description.sponsorshipPenelitian Hibah Pasca 2016en_US
dc.language.isoiden_US
dc.relation.ispartofseriesPenelitian Hibah Pasca;2016
dc.subjectAnopheles sundaicusen_US
dc.subjectcytokinesen_US
dc.subjectIgGen_US
dc.subjectimmune responseen_US
dc.subjectsalivary gland cine(TBV).en_US
dc.titleANALYSIS OF HUMAN IMMUNE RESPONSE AGAINST PROTEIN EXTRACT FROM SALIVARY GLANDS OF Anopheles sundaicus IN MALARIA ENDEMIC AREAen_US
dc.typeOtheren_US


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